Songbirds and humans have evolved unique brain pathways for vocal learning that are critical for song and speech. Brain transcriptomes have recently identified convergent gene expression in specific song nuclei of song-learning birds and speech areas of the brain in humans relative to vocal non-learners. A majority of the associated genes function in motor control and brain connectivity. The strongest shared profiles relate bird motor and striatal song-learning nuclei with human laryngeal motor cortex and the striatum that controls speech production and learning. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.